Samueli A, Hill R, Gillam D. Bioactive glasses in the management of dentine hypersensitivity: a review. Colgate Sensitive Toothpaste - Colgate Professional Helps repair teeth by forming a mineral layer that re-constructs the sensitive part of the tooth, with regular use; Seals the open nerve channels for instant relief, and helps prevent sensitivity from re-occurring; Plus the freshness you trust from Colgate However, the manufacturers of the tested dentifrices were acknowledged in the study [34], so information bias wasexpected in the conducted trial. Colgate Pro relief Sensitive pasta 75ml - Opinie i ceny na Ceneo.pl Post-application changes on SCASS were observed after one minute, three days, two, four, and six weeks, subsequently. For instant relief, apply directly to each sensitive tooth surface and massage for one minute, up to twice a day. 2010;21(2):428. Colgate Sensitive PRO-Relief provides you relief from sudden shocks of pain and long-term sensitivity with regular use. Colgate Sensitive Pro-relief Multi Protection Toothpaste 110g Click & Collect. Participants were asked to pick up the envelope from the box. J Dent Res. Moreover, FCPS as a new bioactive material revealed promising potency of sustainable management of DH in a previously conducted trial by Ashwini et al. Written informed consent was obtained with a signed agreement plan to visit for six weeks at interim efficacy intervals of day three, week two, week four, and week six. These commercially available tooth paste are one n the same thing.Both says they work in reducing the tooth senstivity due to cold intake.These may help olny during the early stages but when there is sensation to both cold and hot drinks and pain, you need to visit a dentist. Poster #0742, March 2018 AADR. Colgate Sensitive Pro-relief 110g - Alpro Pharmacy 2023 BioMed Central Ltd unless otherwise stated. Plus it has the freshness you trust from Colgate! The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. J Clin Periodontol. J Oral Sci. All authors read and approved the final manuscript. Colgate SENSITIVE PRO-Relief has been rebranded to Colgate SENSITIVE INSTANT Relief . Colgate Sensitive Instant Relief Tandkrm 75 ml - Apotek Hjrtat [10] examined the evidence for strontium acetate and Pro-argin in 2018, and their findings depicted low quality of evidence for strontium acetate on the Grading of Recommendations, Assessment, Development, and Evaluations system (GRADE). Gillam D, Hill R, Samueli A. Bioactive glasses in the management of dentine hypersensitivity: a review. Ingredients *Potassium Nitrate Last updated on May 11, 2021. It contains clinically proven Pro-Argin technology which provides instant and lasting sensitivity relief. Written consent was obtained from all participants to participate in the six-week clinical trial. J Oral Rehabil. Mockdeci H, Polonini H, Martins I, Granato A-P, Raposo N. Evaluation of ex vivo effectiveness of commercial desensitizing dentifrices. It remains a prevalent global disease with two different treatment modalities of home-care desensitisation with the over-the-counter (OTC) desensitisers such as potassium, Balevi B. For lsting relief, apply to a gentle toothbrush making sure to brush all . Colgate-Palmolive Company 2018. compared the Pro-Argin formulation with a calcium sodium phosphosilicate toothpaste, demonstrating 88% versus 50% occlusion respectively. 2017;2017:2. Compend Contin Educ Dent. 2015;28(1):404. Effect of dentin hypersensitivity treatment on oral health related quality of lifea systematic review and meta-analysis. The Pro-Argin technology repairs sensitive areas of the teeth for instant* and long-lasting sensitivity pain relief. Desensitizing toothpastes for dentin hypersensitivity: a network meta-analysis. Dentinal tubules occluded by bioactive glass-containing toothpaste exhibit high resistance toward acidic soft drink challenge. Mantzourani M, Sharma D. Dentine sensitivity: past, present and future. Prevalence of dentin hypersensitivity: systematic review and meta-analysis. Privacy Colgate Sensitive Pro-Relief Instant Relief Sensitive Toothpaste - 75ml Colgate Sensitive Pro-relief Repair & Prevent How does Colgate Sensitive Pro-Relief Repair & Prevent work? Colgate Sensitive Instant Relief Whitening Toothpaste 75 ml Pack of 5, Blocks Pain Instantly, Prevents Sensitivity, Gently Removes Stains (5 x 75 ml) 1,230 5 offers from 12.50 Colgate Sensitive Pro Relief Enamel Repair Toothpaste 75ml - 4 packs 94 22 offers from 14.14 Colgate Sensitive Instant Relief Enamel Repair Toothpaste 75 ml 190 Colgate Sensitive Pro-Relief works by plugging the channels to block tooth sensitivity and with regular use, it builds a long-lasting protective barrier that acts like a seal against sensitivity. & Farooqui, W.A. Ayad F, Ayad N, Zhang YP, DeVizio W, Cummins D, Mateo LR. Therefore, in the current study, we used a dental explorer and the air blast and water jet stimuli from the triple syringe of the dental unit for testing DH to control the subjective variations in treatment response. While 8% strontium acetate showed a greater clinical reduction in water jet stimulated DH on VAS than Pro-argin at all efficacy intervals, as demonstrated in Table 6. With regular use, it reduces teeth sensitivity and helps to strengthen gums and prevent gum recession. Colgate Sensitive Pro-Relief efektywnie i szybko znosi nadwraliwo zbw, zamyka kanaliki zbinowe w ktrych s zakoczenia nerww, dziki czemu blokuje bl. When it begins to interfere with oral hygiene, it can also lead to poor oral health outcomes. Tel: +381 (0)21 452-910, +381 (0)21 420-758. These ingredients resulted in rapid fluorapatite crystallisation at exposed tubular ends of dentin [12]. No side effects, apart from money not well spent. Table 3 demonstrates the percent change in the mean scores of DH on SCASS relative to baseline within the group for each treatment arm. 2020;20(3):101460. It improves gum health and helps reduce factors that contribute to gum recession, a leading cause of tooth sensitivity. PubMed Dent Health Curr Res. These dentifrices were extracted in a plain tube by the dental assistant from commercial packing and labelled with treatment codes to keep the principal investigator and participants blinded at the time of treatment assignment. All participants were instructed to dry the tooth surface with the cotton ball and apply a paste of about half-inch length on the dried surface for one minute, then brush the teeth twice daily after breakfast and before sleep as per directions demonstratedon the study model. Colgate SENSITIVE INSTANT Relief Repair & Prevent Toothpaste contains Sodium Fluoride (1450ppmF) the recommended fluoride level for effective caries prevention.4. Dentifrices-containing Pro-argin showed a significant reduction in DH with mean scores of (4.201.70) followed by strontium acetate (4.651.87) followed by FCPS (5.101.88) one minute after application. BMC Oral Health SCASS and VAS were introduced on each visit as primary and secondary outcome measures, respectively. However, Pro-argin showed more clinical improvement in air blast and mechanically stimulated DH compared to 8% strontium acetate, as shown in Tables 4 and 5. Colgate Sensitive Pro-Relief Challenge Advert April 2012 Colgate Sensitive Instant* Relief Enamel Repair Toothpaste gives you clinically proven lasting relief** from sensitivity for 8 weeks when you use it twice a day. Comparative evaluation of the efficacy of three commercially available toothpastes on dentin hypersensitivity reduction: an 8-week clinical study. A randomised, controlled, triple-blinded clinical trial was conducted with 140 participants clinically diagnosed with DH and equally randomized into four groups with parallel treatment assignment of FCPS, Pro-Argin, 8% strontium acetate, and sodium fluoride-based OTC dentifrices, and tested for DH with air blast, mechanical, and water jet stimuli on SCHIFF cold air sensitivity scale (SCASS) and visual analogue scale (VAS) at interim efficacy intervals of one minute, three days, two, four, and six weeks, subsequently. Sensitive Pro-Relief Repair & Prevent Fluoride Toothpaste, 75 ml Based on the synthesis of study results, we can conclude that Pro-argin in Colgate Sensitive Pro-relief and 8% strontium acetate in Sensodyne Rapid Action both are effective for pain relief in one minute after application in DH with better immediate treatment response of Pro-argin than strontium acetate. Blocks the pain of sensitive teeth. Arshad, S., Zaidi, S.J.A. It was found statistically significant relative to control on all clinical parameters of the SCASS and VAS. The strength of this study was that participants were randomised into four treatment groups to generalise the results for the population [32]. A previously published study by Samueli et al. Colgate Sensitive Instant Relief Enamel Toothpaste with Pro-Argin technology to help seal and repair the sensitive areas of teeth. For instant relief, just apply directly to the sensitive tooth with fingertip and gently massage for one minute. Identifier NCT 04249336. Oral dentifrices have been marketed for pain relief within a minute for DH. The arginine, calcium carbonate and phosphate plug created by Colgate Sensitive Pro Relief remains intact with ongoing use, even when exposed to acid challenges. Colgate* Sensitive Pro-Relief TM/MC Toothpaste with Pro-Argin TM/MC Technology is the first toothpaste that is clinically proven to provide instant & lasting relief from dentin hypersensitivity. Colgate Sensitive Pro Relief - an advanced multi-benefit solution for Colgate Tandpasta Sensitive Instant Relief Whitening. For best performance, keep cap closed when not in use. Results of our study, together with the results of the previous studies, confirm the immediate clinical efficacy of Pro-argin for the relief of DH. We discuss how this innovative technology works to provide patients with rapid and long-lasting relief from dentin hypersensitivity. There was a significant (p<0.001) reduction of 45.7% with Pro-argin, 37.6% with 8% strontium acetate, 18.1% with FCPS, and 15.2% with NaF-based dentifrices relative to baseline on SCASS after one-minute application on sensitive teeth. Read our disclaimer for details. Mintsmak. Pro-argin resulted in the immediate treatment response and statistically significant (p<0.001) clinical reduction in DH than FCPS in the present study, as shown in Table 3. Gentle whitening formula. KruskalWallis test was used to compare treatment groups. Participantswere strictly advised to refrain from acidic food and drink intake at least four hours before following up visit. Colgate Sensitive Pro-Relief Complete Protection sensitivity toothpaste is clinically proven for instant and lasting relief from sensitivity pain. Part of Favaro Zeola L, Soares PV, Cunha-Cruz J. J Clin Periodontol 42 (2015), 17, 4. Dentin hypersensitivity (DH) is a sharp toothache that influences a patients' oral health-related quality of life. The Gum Health Physical is a new interactive digital tool you can use to quickly evaluate your patients in-office, and give them a personalized report they can use at home. Find products and services. Dentine hypersensitivity. 3 Report Deon Hines-0003, 2016. All rights reserved. The relief from sensitivity offered by Colgate Sensitive Pro Relief is proven to last. Colgate Sensitive Pro-Relief - Colgate Palmolive Table 4 demonstrates a comparison between treatment groups observing better clinical efficacy in managing DH on SCASS. Colgate Sensitive Pro Relief was found to achieve 91% dentin occlusion, compared to 67% for the stannous fluoride toothpaste. Understanding how Colgate Sensitive Pro Relief works - Dentistry Online These participants were randomized equally by the principal investigator into four entitled treatment arms using computer-generated random sequence numbers, and treatments were allocated randomly using sequentially numbered, opaque, sealed, and stapled envelopes (SNOSE). Colgate Sensitive Instant Relief Whitening Toothpaste 75ml More robust trials with a large number of participants are recommended for furtherassessing the impact of DH on the oral health-related quality of life and the difference in the effectiveness of treatments. Cookies policy. J Clin Dent 20 (2009), special issue 17-22, 3. This toothpaste really does not help at all with symptoms of sensitive teeth. Colgate Sensitive Pro-Relief Whitening - Colgate Professional According to Holland's guidelines of conducting a trial for managing DH, two diagnostic tools are sufficient for quantitative assessment of the clinical efficacy of desensitisers. In addition, one-Way ANOVA with Post Hoc Tukey for pair-wise comparison was used to compare treatment groups computing percent change from baseline with formula (post-application mean scores-baseline mean scores/baseline mean scores). Bakri MM, Hossain MZ, Razak FA, Saqina ZH, Misroni AA, Ab-Murat N, et al. WAF has contributed to revising the manuscript critically and contributed to statistical analyses. Dentine hypersensitivity (DH) is a chronic condition with acute, transient pain in non-carious teeth that originates in response to thermal stimuli such as hot or cold, chemicals like acidic or sweet or salt, and mechanical stimuli due to exposure to dentinal tubules without any apparent clinical disease [1]. A meta-analysis by Grnberg et al. This clinical trial was not funded by any agency in public, commercial or not-for-profit sectors. Colgate Sensitive Pro-Relief Multi Protection Toothpaste provides clinically proven instant and lasting relief for sensitive teeth For instant relief, apply directly to each sensitive tooth with finger tip and gently massage for 1 minute, up to twice daily Clinical efficacy of BioMin F, Colgate sensitive pro-relief and Sensodyne rapid action dentifrices in DH [Internet]. Work with Colgate Professional to help provide better oral care to your patients. J Dent. fluorides, arginine, strontium, and bioactive glasses (BAG) [4] and in-office application of bioactive formulations such as glutaraldehyde, resin-based bonding agents and restorative materials, amorphous calcium phosphate based-tooth mousse, and lasers in the dental clinics [5]. Comparative evaluation of desensitizing efficacy of dentifrice containing 5% fluoro calcium phosphosilicate versus 5% calcium sodium phosphosilicate: a randomized controlled clinical trial. Tandkrmen innehller zink fr att strka tandkttet och frhindra att tandkttet drar sig tillbaka, vilket r en av de vanligaste orsakerna till att . J Dent. Colgate Sensitive Pro-Relief toothpastes have been formulated to provide instant and lasting relief from the pain associated with sensitive teeth. All rights reserved. Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. A study evaluating the efficacy of strontium acetate relative to arginine-based dentifrices was conducted by West et al. Delivering better oral health - An Evidence-based toolkit for prevention. For instant relief, just apply directly to the sensitive tooth with fingertip and gently massage for one minute. Shrimathi S. Effect of BiominF, NovaminR, Argin and nanohydroxy particles containing dentifrices on dentine hypersensitivity and gingivitis among 3544 years aged population of Madurai district: a randomized controlled trial (RCT). Based on the outcomes of previous systematic reviews and meta-analysis, the rationale of the present study was to substantiate the claim of immediate pain relief after one-minute application in DH by non-invasive surface application of OTC dentifrices containing Pro-arginin Colgate Sensitive Pro-Relief, and 8% strontium acetate in Sensodyne Rapid Action and other objective was the comparative evaluation of the clinical efficacy of three technologies, BAG-based FCPS in BioMinR F, Pro-argin, and 8% strontium acetate at efficacy intervals of day three, week two, four and six for sustained inhibition of painful stimulus provoking DH as all three are dentinal tubular occluding dentifrices. Besides, these findings of the current study could be related to previously conducted clinical trials indicating the better clinical effectiveness of Pro-argin than strontium acetate against air-blast and tactile stimulus after three days and one week of application [30, 31]. The second objective of the current study was to directly compare the clinical efficacy of FCPS, Pro-argin technology, and strontium acetate-based dentifrices due to their similar mode of action and tubular occluding potential in managing DH [36, 37]. The price for Colgate Sensitive Pro-Relief is set at RM12.80 to avoid being categorized at RM13.00. All the treatment groups subjected to testing in the present study revealed a considerable clinically significant symptomatic reduction in DH relative to the pre-treatment condition that was also statistically significant. Akber A, Ali NS, Shabbir S, Wahid U, Farooqui WA. Colgate Sensitive Pro-Relief Enamel Rebuild - Home Tester Club These then interact to form a complex with positive charge. COLGATE. Am J Dent. Article Tandkrmen remineraliserar tandemaljen fr att ge bttre motstnd mot syraattacker. We provided oral hygiene instructions and ways of relieving their pain from DH to improve their quality of life. A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity. Thank you for your feedback. Colgate Sensitive Pro Relief for sale | eBay Therefore, the current study outcomes were analysed by parametric and non-parametric statistical tests after assessing the normal distribution of data and equality of variances with Shapiro Wilk statistics. For instant relief, apply directly to each sensitive tooth surface and massage for one minute, up to twice a day. Colgate Sensitive Instant Relief Toothpaste 75ml | Dental Care - B&M Sensitive Instant Relief Enamel Repair - Colgate Pro-Argin technology is occlusive. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Colgate Sensitive Pro Relief Whitening for improved stain removal. 2019;88:103170. Indian J Dent Sci. Docimo et al. The prime focus of treatment nowadays is based on the exploration of novel materials to remineralise the exposed tubular endings and mimic and restore the structure of the dentin [11]. The sealed envelope contained details of unique subject numbers assigned individually in ascending order, group titles, and treatment codes and was placed in the box. Innehll Colgate Sensitive Instant Relief Enamel Repair r en fluortandkrm med Pro-Argin-teknologi som ger omedelbar smrtlindring vid ilningar i tnderna. Pro-Argin Technology with arginine and an insoluble calcium compound, zinc and 1450ppm fluoride. PubMed Central Therefore, the first null hypothesis was that mean scores for pain due to DH among different treatment groups for immediate relief remain. SJAZ has contributed to the conception, design, interpretation of results and critically revised the manuscript. Researchers have investigated the clinical efficacy of popular propriety occluding dentifrices containing Pro-argin, strontium acetate, and FCPS formulations for treating DH and have found no adverse effects. Clinical Efficacy Of BioMin F, Colgate Sensitive Pro-Relief And Sensodyne Rapid Action Dentifrices In DH The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Wilcoxon Signed-Rank Test was used to compute mean scores relative to baseline at each time point. Elsevier; 2015. p. 3344. 3. The statistician was also kept blinded. CONCLUSION: The study results support the following conclusions: (1) Colgate Sensitive Pro-Relief toothpaste provides a significantly more reduction in dentin hypersensitivity than Sensodyne. 29,95 kr. Colgate Sensitive Pro Relief was found to achieve 91% dentin occlusion, compared to 67% for the stannous fluoride toothpaste. The treatment difference between Pro-argin and 8% strontium acetate was not statistically significant with a p>0.05 for immediate and sustained pain relief in DH and statistically significant relative to control on all clinical parameters of the SCASS and VAS. 2013;41(2):18794. Learn more about caries in children from the resources provided on this page. Use regularly to enjoy long-lasting relief from sensitivity*. Gently and effectively removes stains. It also strengthens tooth enamel by helping rebuild weak spots. However, they also suggested further comparative evaluations of two dentifrices with large sample sizes as limited scientific evidence was found in previous studies [16]. Colgate Sensitive Pro Relief Instant Relief, Plugging the channels that lead to sensitive tooth nerves to help relieve sensitivity. However, there was no significant treatment difference between dentifrices containing Pro-argin and strontium acetate (p>0.05) at each efficacy interval. *Fr omedelbar lindring ska du applicera direkt p den knsliga . Directions HOW LONG CAN A PATIENT USE Colgate SENSITIVE INSTANT Relief Repair & Prevent? J Clin Dent 20 (2009), special issue 123-130, 2. Lg i kurv. Colgate Toothpaste Sensitive Pro Relief Original - 110g x 5(Free 5x Colgate Toothpaste relieves the discomfort of tooth irritation by still addressing the root causes. Modified bass brushing method was demonstrated on the same model before the first application of dentifrices in the dental clinic. Pro-Argin technology can be found in Colgate Sensitive Pro Relief Toothpaste, sold as Colgate Sensitive Instant Relief in the UK and elmex Sensitive Professional in Europe. For instant relief, just apply directly to the sensitive tooth with finger tip and gently massage for one minute. YYYY Colgate-Palmolive Company. Participants analyzed per group were more than thirty fulfilling the requirement of Holland's guidelines for conducting clinical trials for the management of DH [42]. Pro-Argin technology provides instant* and long-lasting, Oral Care Products | Colgate Professional. 2016;27(4):916. Colgate Sensitive Pro-Relief r en tandkrm som ger omedelbar och varaktig lindring mot ilningar i tnderna. 5 Hines D et al. Provides 24/7 sensitivity protection. Hu et al. Barbie Battery Toothbrush for kids+Sensitive Plus Sensitivity Relief 2017;457:2530. Colgate Sensitive Instant Relief Repair & Prevent tandkrm ger dig kliniskt bevisad lngvarig lindring mot ilningar i tta veckor nr du anvnder den tv gnger om dagen. BMC Oral Health 21, 498 (2021). While your patients may have dentine hypersensitivity in common, their oral care needs will vary. [33] again reported a 54% clinical reduction in DH with Pro-argin in eight weeks clinical trial using SCASS. found the clinical efficacy of Pro-argin better than strontium acetate for mechanical and air-blast stimulated DH on VAS and SCASS in follow-up periods of one minute, three days, two, four and eight weeks in a systematic review in 2015. For lasting relief and gum protection, apply twice daily using a sensitive toothbrush, making sure to brush all surfaces of teeth including sensitive areas. J Clin Dent 2009; 20 (Spec Iss): 123-130. Dentin hypersensitivity can have significant detrimental effects on your patients wellbeing and quality of life. blokerer jeblikkeligt smerter fra isninger. Exclusive Pro-Argin formula. Poster #3406, July 2018 IADR. Colgate Sensitive Pro Relief was compared to a leading brand of desensitizing toothpaste containing stannous fluoride in a laboratory study, with confocal laser scanning microscopy and a novel imaging program used to qualify dentinal tubule occlusion. Colgate Sensitive Pro Relief Whitening Toothpaste 75ml tube (Pack of 4) Instant and Lasting Relief Clinically Proven with Active Ingredients We have a surprise for you Find out all personalised promo codes that you are eligible for. The secondary objective of the study was to compare the clinical efficacy of Pro-argin, strontium acetate, and FCPS for immediate and sustained treatment response in DH that was measured on SCASS as a primary outcome measure and VAS as secondary outcome measure at efficacy intervals of one minute, day-three, week two, four and six. Colgate Sensitive Pro-Relief Instant Relief Sensitive Toothpaste - 75ml More Images Colgate Sensitive Pro-Relief Instant Relief works as a shield that blocks pathways to pain instantly. To alleviate their tooth sensitivity problem, by using Colgate Sensitive Pro-Relief will give them lasting relief and they can drink ice water freely. Hence, the current study outcomes, along with previously published findings, corroborate the in vitro findings of obliteration of dentinal tubules with strontium acetate impeding painful fluid movement in dentine [29]. OTC dentifrices were applied and massaged gently with the applicator on at least two sensitive teeth per subject at two different sites, including cementoenamel junction and exposed dentinal surface, by the doctor in the office during the first visit. Int J Dent. Directions *For instant relief, apply directly to the sensitive tooth with fingertip, and massage gently for 60 seconds, one a week or less frequently **For lasting relief, apply to a gentle toothbrush making sure to brush all sensitive areas of the teeth. Was this answer helpful? The secondary analysis population could be described as 20 participants per treatment group out of 35 enrolled in the six-week trial who responded to mechanical and water jet stimuli on VAS with scores of4 as secondary outcome measures. Holland G, Narhi M, Addy M, Gangarosa L, Orchardson R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. Klubpris: 25,46 kr. . All rights reserved. Formulated with Pro-Argin technology, Colgate Sensitive Pro-Relief is clinically proven instant and lasting sensitivity relief*. Google Scholar. This toothpaste prevents sensitivity coming back by building a protective barrier that acts like . Nathoo S, Delgado E, Zhang YP, DeVizio W, Cummins D, Mateo LR: Comparing the efficacy in providing instant relief of dentine hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride and to a control toothpaste with 1450 ppm fluoride: A three-day clinical study in New Jersey, USA. Clinically proven amino acid formula with Pro-Argin technology to provide sensitivity relief. Colgate Sensitive Instant Relief - Colgate Professional Brush twice daily. The effectiveness of Colgate SENSITIVE INSTANT Relief toothpaste is built on its Pro-Argin technology with arginine and calcium from calcium carbonate. 1997;24(11):80813. Colgate Sensitive Pro-Relief Enamel Rebuild also: Fights cavities Strengthens enamel Freshens breath Vegan . Moreover, there was no significant difference between dentifrices containing FCPS, Pro-argin, and 8% strontium acetate (p>0.05) on completion of trial after six weeks.
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